Change in Lab Methodology
for D-Dimer Testing

BACKGROUND:

On April 17, 2018, the laboratory methodology used for D-dimer testing will change from a manual method (Vidas) to an automated method (STA®- Liatest® D-Di). For exclusion of deep vein thrombosis (DVT) and pulmonary embolism (PE), the new method has a negative predictive value comparable to that of our present assay. Because this new test is automated, it will also replace our manual D-dimer test presently used for confirming disseminated intravascular coagulation (DIC). Please be aware that the quantification units used for the new automated method will differ from those presently used for DIC confirmation as indicated below.

METHODOLOGY & REPORTING:

EFFECTIVE DATE:
April 17, 2018

SPECIMEN REQUIREMENT AND TESTING INFORMATION:
	Specimen: 1.0 mL citrate plasma (blue top tube)
	Test Methodology: Latex particle microagglutination measured by photometry
	Test Codes: DDIMER, DDT
	Turnaround Time (TAT):
		STAT: 60 minutes Routine: 2 – 4 hours
	Stability:
		Ambient: 4 hours Refrigerated: Unacceptable Frozen: 2 weeks
	Rejection Criteria: SPECIMENS COLLECTED IN GLASS TUBES, specimens that exceed stated stability, unlabeled/mislabeled/mismatched specimens and specimens submitted in leaking containers, clotted, hemolyzed, or underfilled tubes.

A summary of all tests offered by our Laboratory Services can be found here: http://www.pathology.uci.edu/services/index.asp

Sincerely,

Richard S. Newman, MD
Director, Coagulation Laboratory

Edwin S. Monuki, MD, PhD
Chair, Department of Pathology & Laboratory Medicine