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Unit Measurement Change for IgG Subclasses 1, 2, 3, 4
In an effort to provide consistent reporting with total IgG, and in consultation with UCI’s Institute for Immunology, the Department of Pathology will change the units for IgG subclasses from mg/L to mg/dL.

Reference intervals remain in accordance with the manufacturer’s recommendations. The adult serum reference intervals were verified in 24 adult blood donors. Pediatric ranges will also be maintained in accordance with manufacturer’s recommendations.

Test Name Test Code Previous Adult Reference Interval (mg/L) Updated Adult Reference Interval (mg/dL)
Immunoglobulin IgG Subclass 1 IGGSUB 3824 - 9286 mg/L 382 - 929 mg/dL
Immunoglobulin IgG Subclass 2 IGGSUB 2418 - 7003 mg/L 242 - 700 mg/dL
Immunoglobulin IgG Subclass 3 IGGSUB 218 - 1761 mg/L 22 - 176 mg/dL
Immunoglobulin IgG Subclass 4 IGGSUB, IGG4 52 - 1250 mg/L 5 - 125 mg/dL

Effective date: Nov. 14, 2019

Specimen requirement and testing information:

Specimen: Serum

Test methodology: Turbidimetry

Test codes: IGGSUB, IGG4

IGGSUB Minimum stability (after separation from cells):
Ambient: Unacceptable
Refrigerated: 3 days (IgG1, IgG2), 8 days (IgG3, IgG4, IgG)
Frozen: 1 month

IGG4 Minimum stability (after separation from cells):
Ambient: Unacceptable
Refrigerated: 8 days
Frozen: 1 month

Turnaround time (TAT):
Routine: 1 - 4 days
Set Up Days: M, W, F

Rejection criteria:
Samples containing particulate matter, and lipemic or hemolyzed specimens. Specimens that exceed stated stability, unlabeled/mislabeled/mismatched specimens, specimens submitted in leaking containers, or specimens received with insufficient amounts for testing.

A summary of all tests offered by our laboratory services can be found here:


Bridgit O. Crews, PhD, DABCC
Clinical Chemistry & Toxicology

Edwin S. Monuki, MD, PhD
Department of Pathology & Laboratory Medicine
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