California State Legislation SB-179 formally recognizes the nonbinary gender. Certain laboratory tests have reference ranges established by biological male and female sex (sex-specific reference ranges). For these tests, reference ranges for nonbinary individuals are not yet established.
For patients with nonbinary gender or unknown sex, and have a laboratory test with sex-specific reference ranges within the UCI laboratory system, the male and female reference ranges will be provided with the test result in Epic reports. Flagging for tests with sex-specific ranges will occur outside of the overlap between male and female ranges.
Comments regarding reference ranges and abnormal flagging for patients with nonbinary gender or unknown sex will be provided at the bottom of Epic reports:
Comments for Nonbinary Gender or Unknown Sex
Both male and female reference ranges are provided above because a reference range for nonbinary individuals is not yet established. For nonbinary gender or patients with unknown sex, recommend correlation with the most appropriate range.
Results that fall outside the overlap of male and female reference ranges are flagged for patients with nonbinary gender or unknown sex. Correlation with the most appropriate range is recommended to determine if the flagged result is clinically significant.
Critical values within the UCI laboratory system will be flagged as critical for all patients. All other laboratory tests in the UCI laboratory system will be reported as usual for all patients.
Reference ranges for tests with sex-specific reference ranges are provided in the table below:
Test Name | Age | Female Reference Range | Male Reference Range |
Albumin | >1 year | 3.7—5.3 g/dL | 4.2—5.5 g/dL |
Apoprotein A1 | All ages | 101—199 mg/dL | 94—178 mg/dL |
Apoprotein B | All ages | 49—103 mg/dL | 52—109 mg/dL |
Copper | >11 years | 85—155 mcg/dL | 70—140 mcg/dL |
Creatinine | All ages | 0.6—1.2 mg/dL | 0.7—1.3 mg/dL |
Dehydroepiandrosterone sulfate | >13 years | 80—560 ug/dL | 35—430 ug/dL |
Erythrocyte Sedimentation Rate (ESR) |
Neonates Childrens to Puberty To age 50 years > age 50 years |
0–2 mm/hr 0–13 mm/hr
0–30 mm/hr |
0—2 mm/hr 0—13 mm/hr 0—15 mm/hr 0—20 mm/hr |
Estradiol |
Non-Pregnant |
<33 pg/mL | |
Ferritin | All ages | 10—107 ng/mL | 23—233 ng/mL |
Free Protein S Antigen | >19 years | 50—134% | 70—148% |
Follicle Stimulating Hormone (FSH) | Mid-Follicular Phase: 3.8—8.8 mlU/mL Mid-Cycle Peak: 4.5—22.5 mlU/mL Mid-Luteal Phase: 1.8—5.1 mlU/mL Post-Menopausal: 16.5—113.6 mlU/mL |
1.3—19.3 mlU/mL | |
Glucose Tolerance 1 Hour Post-Prandial | >15 years | 57—145 mg/dL | 63—157 mg/dL |
Growth Hormone | >18 years | 0—10 ng/mL | 0—1 ng/mL |
Hematocrit | 1—17 years | 34—44% | 37—49% |
Hematocrit | >18 years | 34—44% | 39.5—50% |
Hematocrit (Blood Gas) | All ages | 38—46% | 43—51% |
Hemoglobin | 12—17 years | 11.5—15.0 g/dL | 13.0—16.0 g/dL |
Hemoglobin | >18 years | 11.5—15.0 g/dL | 13.0—16.9 g/dL |
Insulin (random level) | 3—9 years | 4.0—40.7 mlU/mL |
2.9—30.9 mlU/mL |
Insulin (random level) | 10—12 years | 7.9—56.2 mlU/mL |
6.3—50.1 mlU/mL |
Insulin (random level) | 13—14 years | 7.9—56.2 mlU/mL |
7.9—50.1 mlU/mL |
Insulin (random level) | 15—17 years | 7.4—51.3 mlU/mL |
7.1—66.1 mlU/mL |
Iron | 0—15 years | 30—127 mcg/dL |
30—110 mcg/dL |
Iron | >16 years | 37—170 mcg/dL |
49—181 mdg/dL |
Luteinizing Hormone (LH) | Mid-Follicular Phase: 2.1—10.9 mlU/mL Mid-Cycle Peak: 19.2—103.0 mlU/mL Mid-Luteal Phase: 1.2—12.9 mlU/mL Post-Menopausal: 10.9—58.6 mlU/mL |
1.2—8.6 mlU/mL |
|
Myoglobin | All ages | 0—50 ng/mL |
0—65 ng/mL |
O2 Content | All ages | 16.0—21.5 mL/dL |
17.5—23.0 mL/dL |
Progesterone |
Mid-Follicular Phase: 0.3—1.5 ng/mL Pregnancy |
0.1—2.1 ng/mL |
|
Prolactin |
Pre-Menopausal: 3.3—26.7 ng/mL |
2.6—13.1 ng/mL |
|
RBC | >13 years |
3.70—5.00 mill/mcL |
4.38—5.62 mill/mcL |
Sex Hormone Binding Globulin | 20—49 years |
17—136 nmol/L |
13—90 nmol/L |
ST2 | >18 years |
0.0—38.7 ng/mL |
0.0—52.0 ng/mL |
Testosterone (% free testosterone) | >20 years |
0.2—0.4% |
0.3—0.4% |
Uric Acid | All ages |
2.3—6.6 mg/dL |
4.4—7.6 mg/dL |
Uric Acid, Urine | All ages |
250—750 mg/total volume |
250—800 mg/total volume |
Urinalysis (epithelial cells and squamous cells) | All ages |
0—10/HPF |
0—5/HPF |
Estimated Glomerular Filteration Rate (GFR): For non-binary individuals or unknown sex, the MDRD equation for female sex is used to calculate the estimated glomerular filtration rate (GFR). To estimate the GFR for male sex, multiply the estimated GFR result by 1.348.
Cystatin C with eGFR: For non-binary individuals or unknown sex, cystatin C-based eGFR is calculated for female sex. To estimate the eGFR for male sex, multiply the cystatin C-based eGFR result by 1.07.
Updated 12/9/2020